Article
Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.
eLife - 19 Apr 2021
Onur Tarik Seref, Laitman Andrew, Zhao He, Keyho Ryan, Kim Hyemin, Wang Jennifer, Mair Megan, Wang Huilan, Li Lifang, Perez Alma, de Haro Maria, Wan Ying-Wooi, Allen Genevera, Lu Boxun, Al-Ramahi Ismael, Liu Zhandong, Botas Juan
Abstract excerpt
Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington's disease (HD), we profiled the gene expression alterations of Drosophila expressing human mutant Huntingtin (mHTT) in either glia or neurons and compared these changes to what is observed in HD human...
Topics
- Animals
- Behavior, Animal
- Brain
- Case-Control Studies
- Cell Adhesion Molecules, Neuronal
- Cell Line
- Disease Models, Animal
- Drosophila Proteins
- Drosophila melanogaster
- Electrical Synapses