Article
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.
Nature communications - 7 Jun 2016
Benraiss Abdellatif, Wang Su, Herrlinger Stephanie, Li Xiaojie, Chandler-Militello Devin, Mauceri Joseph, Burm Hayley B, Toner Michael, Osipovitch Mikhail, Jim Xu Qiwu, Ding Fengfei, Wang Fushun, Kang Ning, Kang Jian, Curtin Paul C, Brunner Daniela, Windrem Martha S, Munoz-Sanjuan Ignacio, Nedergaard Maiken, Goldman Steven A
Abstract excerpt
The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by neonatally engrafting immunodeficient mice with mutant huntingtin (mHTT)-expressing human glial progenitor cells (hGPCs), derived from either human embryonic stem cells or mHTT-transduced fetal hGPCs. Here we show that mHTT glia...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.