Article
Glia are critical for the neuropathology of complex I deficiency in Drosophila.
Human molecular genetics - 1 Sept 2014
Hegde Vijay R, Vogel Rutger, Feany Mel B
Abstract excerpt
Mitochondrial electron transport chain (ETC) disorders cause severe neurological disease, typically in the context of fatal encephalomyelopathies. Neuronal cell autonomous energy deficiency due to reduced mitochondrial adenosine triphosphate production is currently the leading hypothesis to explain the neurotoxicity in ETC disorders. To define the mechanisms underlying neuropathology in ETC disorders, we have...
Topics
- Animals
- Drosophila melanogaster
- Electron Transport Complex I
- Gene Knockdown Techniques
- Mitochondria
- Neuroglia
- Neurotoxins
- Phenotype