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Article

Impairment of the glial phagolysosomal system drives prion-like propagation in a <i>Drosophila</i> model of Huntington’s disease

2023-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Protein misfolding, aggregation, and spread through the brain are primary drivers of neurodegenerative diseases pathogenesis. Phagocytic glia are responsible for regulating the load of pathogenic protein aggregates in the brain, but emerging evidence suggests that glia may also act as vectors for aggregate spread. Accumulation of protein aggregates could compromise the ability of glia to elimina...

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Literature Corpus work
6d0d7a73-92d9-569f-8bac-47d0f7e19420
DOI
10.1101/2023.10.04.560952
Open publication

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Impairment of the glial phagolysosomal system drives prion-like propagation in a <i>Drosophila</i> model of Huntington’s diseaseDOI 10.1101/2023.10.04.560952
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