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Article

CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer

13 Feb 2020

Abstract excerpt

Given that colorectal cancer stem cells (CCSCs) play key roles in the tumor dormancy, metastasis, and relapse, targeting CCSCs is a promising strategy in cancer therapy. Here, we aimed to identify the new regulators of CCSCs and found that Cullin 4B (CUL4B), which possesses oncogenic properties in multiple solid tumors, drives the development and metastasis of colon cancer by sustaining cancer stem-like features....

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PMID: 32054830
DOI: 10.1038/s41389-020-0206-3

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