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Article

Enhancing portability of trans-ancestral polygenic risk scores through tissue-specific functional genomic data integration.

PLoS genetics - 1 Aug 2024

Crone Bradley, Boyle Alan P

Abstract excerpt

Portability of trans-ancestral polygenic risk scores is often confounded by differences in linkage disequilibrium and genetic architecture between ancestries. Recent literature has shown that prioritizing GWAS SNPs with functional genomic evidence over strong association signals can improve model portability. We leveraged three RegulomeDB-derived functional regulatory annotations-SURF, TURF, and TLand-to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39110742
DOI: 10.1371/journal.pgen.1011356
PMCID: PMC11333000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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