Article

ERK signaling integrates multiple mechanisms to drive cortical evolutionary expansion

2026-07-28

Abstract excerpt

A critical first step in human evolutionary divergence from chimpanzees and other primates is the production of greatly increased numbers of cortical pyramidal neurons during development and over evolutionary time. This expansion underpins the enlarged human cerebral cortex and, consequently, higher-order cognition and consciousness. However, the cellular and molecular mechanisms driving this progressive increase...

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Literature Corpus work: 4dbfcc09-b8fc-5f8c-9f6f-d5f4b4e759d8
DOI: 10.64898/2026.07.28.741115

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