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Article

FGF-MAPK signaling regulates human deep-layer corticogenesis.

Stem cell reports - 11 May 2021

Gantner Carlos W, Hunt Cameron P J, Niclis Jonathan C, Penna Vanessa, McDougall Stuart J, Thompson Lachlan H, Parish Clare L

Abstract excerpt

Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are generated from a single founder population of neuroepithelial stem cells. However, how these progenitors alter their layer competence over time remains unknown. Here, we used human embryonic stem cell-derived cortical progenitors to examine the role of fibroblast growth factor (FGF) and Notch signaling in influencing...

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Identifiers

PMID: 33836146
DOI: 10.1016/j.stemcr.2021.03.014
PMCID: PMC8185433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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