Article

Integrated ERK, PKA, YAP/TAZ, and SHH Signaling Drives Cortical Lineage Diversification and Evolutionary Expansion

2025-04-09

Abstract excerpt

The human cerebral cortex, essential for intelligence, cognition, and language, evolved its uniqueness through mechanisms that drive neuronal expansion. Here, we demonstrate that ERK and PKA signaling cooperatively preserve the neurogenic capacity of cortical radial glia (RGs) by inhibiting gliogenic YAP/TAZ and SHH signaling. YAP/TAZ signaling drives cortical RGs toward ependymal fate, while SHH signaling facilit...

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Literature Corpus work: fe454a02-8be5-5b3f-a39b-0cd22d5b5c5b
DOI: 10.1101/2025.04.09.647935

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