Article

Human follicular CD4 T cell function is defined by specific molecular, positional and TCR dynamic signatures

2020-05-13

Abstract excerpt

The orchestrated interaction between follicular helper CD4 T cells (TFH) and germinal center (GC) B cells is crucial for optimal humoral immunity. However, the regulatory mechanisms behind spatial distribution and function of TFH is not well understood. Here, we studied human TFH cells and found that transitioning to a CD57 hi TFH status was associated with distinct positioning in the GC, phenotype, transcription...

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Literature Corpus work: 3e5ee632-5606-5f38-882e-3f6aa4c51292
DOI: 10.1101/2020.05.12.089706

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