Article
T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma.
Blood cancer journal - 18 Aug 2023
Yang Zhi-Zhang, Kim Hyo Jin, Wu Hongyan, Tang Xinyi, Yu Yue, Krull Jordan, Larson Daniel P, Moore Raymond M, Maurer Matthew J, Pavelko Kevin D, Jalali Shahrzad, Pritchett Joshua C, Mudappathi Rekha, Wang Junwen, Villasboas Jose C, Mondello Patrizia, Novak Anne J, Ansell Stephen M
Abstract excerpt
T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore analyzed a cohort of 82 FL patients using CyTOF to determine whether specific T-cell phenotypes were associated with distinct tumor microenvironments and patient outcome. We...
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