Article
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.
Nature communications - 10 May 2016
Pereira Bernard, Chin Suet-Feung, Rueda Oscar M, Vollan Hans-Kristian Moen, Provenzano Elena, Bardwell Helen A, Pugh Michelle, Jones Linda, Russell Roslin, Sammut Stephen-John, Tsui Dana W Y, Liu Bin, Dawson Sarah-Jane, Abraham Jean, Northen Helen, Peden John F, Mukherjee Abhik, Turashvili Gulisa, Green Andrew R, McKinney Steve, Oloumi Arusha, Shah Sohrab, Rosenfeld Nitzan, Murphy Leigh, Bentley David R, Ellis Ian O, Purushotham Arnie, Pinder Sarah E, Børresen-Dale Anne-Lise, Earl Helena M, Pharoah Paul D, Ross Mark T, Aparicio Samuel, Caldas Carlos
Abstract excerpt
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have copy number aberration (CNA), gene expression and long-term clinical follow-up data. We identify 40 mutation-driver (Mut-driver) genes, and determine associations between mutations, driver CNA...
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