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Paternal folate deficiency reveals meiosis as a metabolic sensing window in the male germline

2026-04-26

Abstract excerpt

Folate-dependent one-carbon metabolism supplies methyl donors required for chromatin modification, yet how metabolic conditions shape epigenome establishment in the male germline remains poorly understood. Here, using a folate-deficient mouse model, we identify meiotic prophase I as a metabolically sensitive window in the male germline. By integrating in vivo germline analysis with bulk and single-cell transcripto...

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Literature Corpus work
3e3ddecf-04a1-5a03-9291-473f830ebc40
DOI
10.64898/2026.04.22.720272
Open publication

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Paternal folate deficiency reveals meiosis as a metabolic sensing window in the male germlineDOI 10.64898/2026.04.22.720272
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