Article

One-carbon metabolism is required for epigenetic stability in the mouse placenta

2023-04-06

Abstract excerpt

One-carbon metabolism, including the folate cycle, has a crucial role in fetal development though its molecular function is complex and unclear. The hypomorphic Mtrr gt allele is known to disrupt one-carbon metabolism, and thus methyl group availability, leading to several developmental phenotypes (e.g., neural tube closure defects, fetal growth anomalies). Remarkably, previous studies showed that some of the ph...

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Literature Corpus work: 0cafa880-7d7b-5155-99bb-8b6e8b2c1552
DOI: 10.1101/2023.04.04.535221

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