Article
Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome.
Developmental cell - 21 Dec 2015
Shea Jeremy M, Serra Ryan W, Carone Benjamin R, Shulha Hennady P, Kucukural Alper, Ziller Michael J, Vallaster Markus P, Gu Hongcang, Tapper Andrew R, Gardner Paul D, Meissner Alexander, Garber Manuel, Rando Oliver J
Abstract excerpt
Paternal diet can impact metabolic phenotypes in offspring, but mechanisms underlying such intergenerational information transfer remain obscure. Here, we interrogate cytosine methylation patterns in sperm obtained from mice consuming one of three diets, generating whole genome methylation maps for four pools of sperm samples and for 12 individual sperm samples, as well as 61 genome-scale methylation maps. We...
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