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Article

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

11 Jul 2014

Abstract excerpt

Adverse prenatal environments can promote metabolic disease in offspring and subsequent generations. Animal models and epidemiological data implicate epigenetic inheritance, but the mechanisms remain unknown. In an intergenerational developmental programming model affecting F2 mouse metabolism, we demonstrate that the in utero nutritional environment of F1 embryos alters the germline DNA methylome of F1 adult...

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PMID: 25011554
DOI: 10.1126/science.1255903

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