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Investigating the epigenetic mechanism behind transgenerational inheritance in mice with abnormal folate metabolism

2019-01-01

Abstract excerpt

Exposure to environmental stressors can impact our health and that of future generations even when they are not similarly exposed. How disease risk is inherited is unclear. My thesis focuses on a mouse model of transgenerational inheritance in which folate metabolism is disrupted by a mutation in Methionine synthase reductase (Mtrr^gt). Remarkably, Mtrr⁺/gt heterozygosity leads to an increased likelihood of a wide...

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Literature Corpus work
0420a5ed-b659-5388-a94a-72a0d97ad170
DOI
10.17863/cam.38971
Open publication

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Investigating the epigenetic mechanism behind transgenerational inheritance in mice with abnormal folate metabolismDOI 10.17863/cam.38971
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