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Article

Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

10 Dec 2013

Abstract excerpt

Epidemiological studies suggest that a father’s diet can influence offspring health. A proposed mechanism for paternal transmission of environmental information is via the sperm epigenome. The epigenome includes heritable information such as DNA methylation. We hypothesize that the dietary supply of methyl donors will alter epigenetic reprogramming in sperm. Here we feed male mice either a folate-deficient or...

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PMID: 24326934
DOI: 10.1038/ncomms3889

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