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Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Developmental cell - 8 Mar 2021

Lismer Ariane, Dumeaux Vanessa, Lafleur Christine, Lambrot Romain, Brind'Amour Julie, Lorincz Matthew C, Kimmins Sarah

Abstract excerpt

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression and development. Here, we demonstrate that a folate-deficient (FD) diet alters histone H3 lysine 4 trimethylation (H3K4me3) in sperm at developmental genes and...

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Identifiers

PMID: 33596408
DOI: 10.1016/j.devcel.2021.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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