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Folate-dependent one-carbon metabolism controls meiotic and post-meiotic epigenome remodeling in the male germline

2026-04-28

Abstract excerpt

Environmental exposures can influence offspring health through epigenetic alterations in the male germline. Folate deficiency, a dietary perturbation that disrupts one-carbon metabolism and S-adenosylmethionine (SAM) production, has been linked to altered histone methylation and developmental abnormalities in offspring. However, when and how folate availability shapes the germline epigenome during spermatogenesis...

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Literature Corpus work
1b45fed5-798c-5ae3-9854-acde768dfa17
DOI
10.64898/2026.04.23.720283
Open publication

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