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Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation

19 Jan 2018

Abstract excerpt

Supplementation with high doses of folic acid, an important mediator of one-carbon transfers for DNA methylation, is used clinically to improve sperm parameters in infertile men. We recently detected an unexpected loss of DNA methylation in the sperm of idiopathic infertile men after 6 months of daily supplementation with 5 mg folic acid (>10× the daily recommended intake-DRI), exacerbated in men homozygous for a...

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PMID: 29360980
DOI: 10.1093/hmg/ddy021

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