Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.

Human molecular genetics - 15 Nov 2015

Aarabi Mahmoud, San Gabriel Maria C, Chan Donovan, Behan Nathalie A, Caron Maxime, Pastinen Tomi, Bourque Guillaume, MacFarlane Amanda J, Zini Armand, Trasler Jacquetta

Abstract excerpt

Dietary folate is a major source of methyl groups required for DNA methylation, an epigenetic modification that is actively maintained and remodeled during spermatogenesis. While high-dose folic acid supplementation (up to 10 times the daily recommended dose) has been shown to improve sperm parameters in infertile men, the effects of supplementation on the sperm epigenome are unknown. To assess the impact of 6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dietary Supplements
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Folic Acid

Share to Genes, Regulator

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to snRNP Core Proteins

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 26307085
DOI: 10.1093/hmg/ddv338
PMCID: PMC4614702

Genes

MTHFR
ALDH2
CNTNAP4
DLK1
ERBB2
GABRB3
MEST
NIPA1
PLAGL1
PTPN6
SNRPN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.PMID 26307085Read ↗

Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementationSemantic proximity Read ↗

Folic acid and sperm quality improvement: insights from snRNA sequencing and RNA splicing mechanismsSemantic proximity Read ↗

Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate MetabolismSemantic proximity Read ↗

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.Semantic proximity Read ↗

Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study.Semantic proximity Read ↗

Studying the mechanism of sperm DNA damage caused by folate deficiencySemantic proximity Read ↗

Paternal folate deficiency reveals meiosis as a metabolic sensing window in the male germlineSemantic proximity Read ↗

Transgenerational impact of grand‐paternal lifetime exposures to both folic acid deficiency and supplementation on genome‐wide DNA methylation in male germ cellsSemantic proximity Read ↗

Evaluation of DNA methylation at imprinted DMRs in the spermatozoa of oligozoospermic men in association with MTHFR C677T genotype.Semantic proximity Read ↗

Folate and vitamin B12 in idiopathic male infertilitySemantic proximity Read ↗

Epigenetics of Male Infertility: The Role of DNA MethylationSemantic proximity Read ↗

Low folate in seminal plasma is associated with increased sperm DNA damageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.