Article
Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study.
The American journal of clinical nutrition - 1 Aug 2026
Eigbefoh-Addeh Ailende, Salas-Huetos Albert, Ramos-Rodríguez Carla, Santos-Calderón Luis A, Agarwal Rashmi, Salas-Salvadó Jordi, Babio Nancy, McCann Adrian, Ueland Per M, Murphy Michelle M
Abstract excerpt
BACKGROUND: Folate-mediated one-carbon metabolism is essential for deoxyribonucleic acid synthesis, methylation, and genomic integrity during spermatogenesis. OBJECTIVES: To study the associations between the status of folate, cobalamin, homocysteine, single nucleotide polymorphisms (SNPs) affecting folate-mediated one-carbon metabolism, and sperm quality. METHODS: In this cross-sectional study, 197 healthy males...
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