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Article

Dynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer.

Scientific reports - 5 Feb 2024

Lu Yuanhua, Li Hui, Zhao Peiyan, Tian Lin, Liu Yan, Sun XiaoDan, Cheng Ying

Abstract excerpt

Small cell lung cancer (SCLC) is heterogenous in phenotype and microenvironment. Dynamic phenotypic reprogramming, leading to heterogeneity, is prevalent in SCLC, while the mechanisms remain incompletely understood. Cancer-associated fibroblasts (CAFs) possess comprehensive roles in cancer progression, while their function in phenotypic reprogramming of SCLC remain elusive. Here, we obtained transcriptome data of...

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Share to Cancer-Associated Fibroblasts
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Identifiers

PMID: 38311608
DOI: 10.1038/s41598-024-52687-z
PMCID: PMC10838940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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