Article
Unraveling phenotypic plasticity and evolution in small cell lung cancer.
Cell systems - 21 Sept 2022
Nath Aritro
Abstract excerpt
Malignant cell populations in a tumor often exist in distinct phenotypic states. Deciphering tumor heterogeneity requires determining how many such unique states exist and what the biological traits associated with each are. Archetype analysis of SCLC transcriptomes reveals key phenotypic states in SCLC tumors and their patterns of evolution.
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