Article

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation

2020-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Lineage plasticity, a capacity to reprogram cell phenotypic identity under evolutionary pressure, is implicated in treatment resistance and metastasis in multiple cancers. In lung adenocarcinomas (LUADs) amenable to treatment with targeted inhibitors, transformation to an aggressive neuroendocrine (NE) carcinoma resembling small cell lung cancer (SCLC) is a recognized mechanism of acquired resis...

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Literature Corpus work: a9d7da06-c6f7-5633-8e7c-6c271dd9014a
DOI: 10.1101/2020.12.02.408476

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