Article
scCircle-seq unveils the diversity and complexity of circular DNAs in single cells
2023-02-24
Abstract excerpt
<title>Abstract</title><p>We describe scCircle-seq, a method for genomically profiling extrachromosomal circular DNAs (circDNAs) in single cells. We implemented and validated scCircle-seq in normal and cancer cell lines, demonstrating that most circDNA species vary between cells and are stochastically inherited during cell division, although their genomic landscape is cell type-specific and can be used to accurate...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 26b78c68-1283-56f1-be42-81d3e7d18d8f
- DOI
- 10.21203/rs.3.rs-2617401/v1