Article
scCircle-seq unveils the diversity and complexity of circular DNAs in single cells
2023-09-22
Abstract excerpt
<title>Abstract</title> <p>Extrachromosomal circular DNAs (ecDNAs) have emerged as important intra-cellular mobile genetic elements that affect gene copy number and exert <italic>in trans</italic> regulatory roles within the cell nucleus. Here, we describe scCircle-seq, a method for genomically profiling ecDNAs and unraveling their diversity and complexity in single cells. We implemented and validated scCircle-se...
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Identifiers and source
- Literature Corpus work
- 776caed5-a0e1-52eb-ab9e-05fe53ff21e9
- DOI
- 10.21203/rs.3.pex-2385/v1