Article

Mutation of TRIM28-Lys304 to Gln Attenuates its Interaction with KRAB-ZNFs and Promotes Differentiation of Erythroleukemic K562 Cells

2020-10-08

Abstract excerpt

<title>Abstract</title> BackgroundTRIM28/KAP1/TIF1β is a key epigenetic modifier. Genetic ablation of <italic>trim28</italic> is embryonic lethal although RNAi-mediated knockdown in somatic cells yields viable cells. Reduction in TRIM28 abundance at the cellular or organismal level results in polyphenism. Posttranslational modifications such as phosphorylation and sumoylation have been shown to regulate TRIM28...

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Literature Corpus work: 3e084d17-d002-5f60-a8d1-6515dd490d4c
DOI: 10.21203/rs.3.rs-85963/v1

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