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An overexpression platform reveals the functional diversity of human KRAB-Zinc Finger Proteins in maintaining cellular homeostasis

2026-04-22

Abstract excerpt

Kruppel associated box zinc finger proteins (KZFPs) form the largest family of transcriptional regulators in mammals, yet most remain uncharacterized. Here we established a scalable framework to probe KZFP function. An arrayed inducible overexpression screen of 366 human KZFPs in K562 cells identified factors that alter cellular proliferation, enabling functional prioritization. Integrative transcriptomic, chromat...

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Literature Corpus work
8e35d088-f1f2-5315-bfb0-d19dd339987d
DOI
10.64898/2026.04.20.718945
Open publication

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An overexpression platform reveals the functional diversity of human KRAB-Zinc Finger Proteins in maintaining cellular homeostasisDOI 10.64898/2026.04.20.718945
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