Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency

21 Sept 2020

Abstract excerpt

Despite the widespread use of anti-retroviral therapy, human immunodeficiency virus (HIV) still persists in an infected cell reservoir that harbors transcriptionally silent yet replicationcompetent proviruses.While significant progress has been made in understanding how the HIV reservoir is established, transcription repression mechanisms that are enforced on the integrated viral promoter have not been fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32956422
DOI: 10.1371/journal.ppat.1008834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latencyPMID 32956422Read ↗

The histone methyltransferase SETD2 regulates HIV expression and latency through a post-transcriptional mechanismSemantic proximity Read ↗

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cellsSemantic proximity Read ↗

A targeted CRISPR screen identifies ETS1 as a regulator of HIV latencySemantic proximity Read ↗

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latencySemantic proximity Read ↗

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulationSemantic proximity Read ↗

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 LatencySemantic proximity Read ↗

Identification of unrecognized host factors promoting HIV-1 latencySemantic proximity Read ↗

The sounds of silencing: dynamic epigenetic control of HIV latencySemantic proximity Read ↗

A targeted CRISPR screen identifies ETS1 as a regulator of HIV-1 latencySemantic proximity Read ↗

A functional map of HIV-host interactions in primary human T cellsSemantic proximity Read ↗

Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoirSemantic proximity Read ↗

A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 StrainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.