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Article

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

International journal of molecular sciences - 6 Jun 2023

Chang Yao-Jen, Lin Steven, Kang Zhi-Fu, Shen Bin-Jon, Tsai Wen-Hai, Chen Wen-Ching, Lu Hsin-Pin, Su Yu-Lun, Chou Shu-Jen, Lin Shu-Yu, Lin Sheng-Wei, Huang Yin-Jung, Wang Hsin-Hui, Chang Ching-Jin

Abstract excerpt

TRIM28/KAP1/TIF1β is a crucial epigenetic modifier. Genetic ablation of trim28 is embryonic lethal, although RNAi-mediated knockdown in somatic cells yields viable cells. Reduction in TRIM28 abundance at the cellular or organismal level results in polyphenism. Posttranslational modifications such as phosphorylation and sumoylation have been shown to regulate TRIM28 activity. Moreover, several lysine residues of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37372979
DOI: 10.3390/ijms24129830
PMCID: PMC10298087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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