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Gata2a maintains <i>cebpa</i> and <i>npm1a</i> in haematopoietic stem cells to sustain lineage differentiation and genome stability

2021-07-19

Abstract excerpt

The transcription factor Gata2 is required to produce and maintain haematopoietic stem and progenitor cells (HSPCs) in development and adult haematopoiesis. Mutations in GATA2 lead to GATA2 deficiency syndrome and predispose patients to acquire leukaemia. Here we use zebrafish gata2a enhancer deletion mutants and single cell transcriptomics to understand how GATA2 mediates survival and differentiation of haematopo...

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Identifiers and source

Literature Corpus work
4659821c-b5d4-5d5d-9004-d1706dd1738d
DOI
10.1101/2021.07.19.452890
Open publication

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Gata2a maintains <i>cebpa</i> and <i>npm1a</i> in haematopoietic stem cells to sustain lineage differentiation and genome stabilityDOI 10.1101/2021.07.19.452890
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