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Article

Mechanism of tethered agonist-mediated signaling by polycystin-1.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2022

Pawnikar Shristi, Magenheimer Brenda S, Munoz Ericka Nevarez, Maser Robin L, Miao Yinglong

Abstract excerpt

Polycystin-1 (PC1) is an important unusual G protein-coupled receptor (GPCR) with 11 transmembrane domains, and its mutations account for 85% of cases of autosomal dominant polycystic kidney disease (ADPKD). PC1 shares multiple characteristics with Adhesion GPCRs. These include a GPCR proteolysis site that autocatalytically divides these proteins into extracellular, N-terminal, and membrane-embedded, C-terminal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35522707
DOI: 10.1073/pnas.2113786119
PMCID: PMC9171645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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