Article
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
The EMBO journal - 21 Mar 2012
Araç Demet, Boucard Antony A, Bolliger Marc F, Nguyen Jenna, Soltis S Michael, Südhof Thomas C, Brunger Axel T
Abstract excerpt
The G protein-coupled receptor (GPCR) Proteolysis Site (GPS) of cell-adhesion GPCRs and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis sequence, but its catalytic mechanism remains unknown. Here, we show that unexpectedly the ∼40-residue GPS motif represents an integral part of a much larger ∼320-residue domain that we termed GPCR-Autoproteolysis INducing (GAIN) domain....
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