Cleavage of N-terminus of polycystin-1 increases calcium permeability of polycystin-1/2 receptor channel complexes.

Abstract excerpt

Mutations on genes encoding polycystin-1 (PC1) and PC2 cause autosomal-dominant polycystic kidney disease. How these 2 proteins work together to exert anticystogenesis remains elusive. PC1 resembles adhesion G-protein coupled receptors and undergoes autocleavage in the extracellular N-terminus to expose a hidden "stalk" region, which is hypothesized to act as a "tethered agonist." Here, we show that WT PC1 and...

Topics

• TRPP Cation Channels
• Animals
• Calcium
• Oocytes
• Humans
• Xenopus laevis
• Polycystic Kidney, Autosomal Dominant