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Article

Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease.

Molecular and cellular biology - 1 Sept 2014

Kurbegovic Almira, Kim Hyunho, Xu Hangxue, Yu Shengqiang, Cruanès Julie, Maser Robin L, Boletta Alessandra, Trudel Marie, Qian Feng

Abstract excerpt

Polycystin-1 (Pc1) cleavage at the G protein-coupled receptor (GPCR) proteolytic site (GPS) is required for normal kidney morphology in humans and mice. We found a complex pattern of endogenous Pc1 forms by GPS cleavage. GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but...

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Identifiers

PMID: 24958103
DOI: 10.1128/MCB.00687-14
PMCID: PMC4135549

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