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The GPCR properties of polycystin-1- A new paradigm

4 Nov 2022

Abstract excerpt

gene, the most frequently mutated gene leading to autosomal dominant polycystic kidney disease (ADPKD). This large (> 462 kDal) protein has a complex posttranslational maturation process, with over five proteolytic cleavages having been described, and is found at multiple cellular locations. The initial description of the binding and activation of heterotrimeric Gαi/o by the juxtamembrane region of the PC1...

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PMID: 36406261
DOI: 10.3389/fmolb.2022.1035507

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