Article

Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists

2024-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Polycystin-1 (PC1) is the membrane protein product of the PKD1 gene whose mutation is responsible for 85% of the cases of autosomal dominant polycystic kidney disease (ADPKD). ADPKD is primarily characterized by the formation of renal cysts and potential kidney failure. PC1 is an atypical G protein-coupled receptor (GPCR) consisting of 11 transmembrane helices and an autocatalytic GAIN domain th...

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Literature Corpus work: 6aea1ddf-bec0-59c3-9eb2-fdf8857c55cd
DOI: 10.1101/2024.01.06.574465

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