Article

Mechanism of Tethered Agonist-Mediated Signaling by Polycystin-1

2021-08-05

Abstract excerpt

Polycystin-1 (PC1) is an important unusual G-protein-coupled receptor (GPCR) with 11 transmembrane (TM) domains and its mutations account for 85% of cases of autosomal dominant polycystic kidney disease (ADPKD). PC1 shares multiple characteristics with Adhesion GPCRs. These include a GPCR proteolysis site that autocatalytically divides these proteins into extracellular, N-terminal and membrane-embedded, C-terminal...

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Literature Corpus work: 5865710a-df81-5568-a967-9c0650cdb08f
DOI: 10.1101/2021.08.05.455255

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