Article

Watching dynamics and assembly of spliceosomal complexes at single molecule resolution

2015-01-01

Abstract excerpt

Splicing plays a major role in eukaryotic gene expression by processing pre-mRNA to form mature mRNA. Splicing is catalysed by the spliceosome; a ribonucleoprotein complex consisting of five small nuclear ribonucleoproteins (snRNPs) and over 100 proteins. Proper assembly of spliceosomal components is critical for its function, and thus assembly defects can be lethal. Several diseases have been associated with spli...

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Literature Corpus work: 3dd08c07-8473-5f21-8451-0b1a87097d17
DOI: 10.25560/33214

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