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Article

snRNP proteins in health and disease.

Seminars in cell & developmental biology - 1 Jul 2018

Krausová Michaela, Staněk David

Abstract excerpt

Split gene architecture of most human genes requires removal of intervening sequences by mRNA splicing that occurs on large multiprotein complexes called spliceosomes. Mutations compromising several spliceosomal components have been recorded in degenerative syndromes and haematological neoplasia, thereby highlighting the importance of accurate splicing execution in homeostasis of assorted adult tissues. Moreover,...

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PMID: 29037818
DOI: 10.1016/j.semcdb.2017.10.011

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