Article

A 2A adenosine receptor activation prevents neutrophil aging and promotes polarization from N1 towards N2 phenotype

2022-05-09

Abstract excerpt

Extracellular adenosine is a biologically active signaling molecule that accumulates at sites of metabolic stress in sepsis. Extracellular adenosine has potent immunosuppressive effects by binding to and activating G protein-coupled A 2A adenosine receptors (A 2A ARs) on the surface of neutrophils. A 2A AR signaling reproduces many of the phenotypic changes in neutrophils that are characteristic of sepsis, includi...

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Literature Corpus work: 3dcc1481-11da-59d3-a6f8-b9eb891353e2
DOI: 10.21203/rs.3.rs-1601722/v1

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