Article

Altered neutrophil G-protein receptor signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

2025-12-17

Abstract excerpt

<h4>Background:</h4> Immune function alters with age, and is often accompanied by chronic, low-grade inflammation (inflammageing). In individuals with frailty, inflammageing is increased, reducing immune function and increasing susceptibility to serious outcomes from infection. In this study we investigated the changes that take place in human neutrophils during healthy ageing and ageing with frailty (FR) using R...

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Literature Corpus work: a3839b1e-5cfc-5d25-83d9-9b55c0af79f2
DOI: 10.64898/2025.12.16.25342352

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