Article
A2A adenosine receptor activation prevents neutrophil aging and promotes polarization from N1 towards N2 phenotype.
Purinergic signalling - 1 Sept 2022
Lovászi Marianna, Németh Zoltán H, Pacher Pál, Gause William C, Wagener Gebhard, Haskó György
Abstract excerpt
Extracellular adenosine is a biologically active signaling molecule that accumulates at sites of metabolic stress in sepsis. Extracellular adenosine has potent immunosuppressive effects by binding to and activating G protein-coupled A2A adenosine receptors (A2AARs) on the surface of neutrophils. A2AAR signaling reproduces many of the phenotypic changes in neutrophils that are characteristic of sepsis, including...
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