Article
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS.
Cellular & molecular immunology - 1 May 2024
Xu Changchang, Zhang Lin, Xu Shaoyu, Wang Zichen, Han Qi, Lv Ying, Wang Xingfang, Zhang Xiangxin, Zhang Qingju, Zhang Ying, He Simeng, Yuan Qiuhuan, Bian Yuan, Li Chuanbao, Wang Jiali, Xu Feng, Cao Yihai, Pang Jiaojiao, Chen Yuguo
Abstract excerpt
Acetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671-ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and...
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