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Article

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.

American journal of respiratory and critical care medicine - 15 Oct 2016

Juss Jatinder K, House David, Amour Augustin, Begg Malcolm, Herre Jurgen, Storisteanu Daniel M L, Hoenderdos Kim, Bradley Glyn, Lennon Mark, Summers Charlotte, Hessel Edith M, Condliffe Alison, Chilvers Edwin R

Abstract excerpt

RATIONALE: Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied. OBJECTIVES: To examine the functional and transcriptional profiles of patient blood and alveolar neutrophils compared with healthy volunteer cells, and to define their...

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Identifiers

PMID: 27064380
DOI: 10.1164/rccm.201509-1818OC
PMCID: PMC5067816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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