Organisational principles of long non-coding RNAs revealed by exon deletion

Abstract excerpt

Long non-coding RNAs (lncRNAs) regulate cell phenotypes in health and disease, yet how function is encoded in their sequence remains poorly understood. Current models propose a modular architecture composed of discrete functional elements, but this is based on a limited set of paradigmatic examples and methods for mapping function to sequence are limited in scope and resolution. Here, we establish a high-throughpu...

Topics

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• Alternative Splicing
• CRISPR-Cas Systems
• Exons
• Genetic Fitness
• HEK293 Cells
• RNA Splice Sites
• TATA-Binding Protein Associated Factors
• Transcription Factor TFIID

Identifiers and source

Literature Corpus work

5ef386b7-80d3-54b1-bf37-668b2c4580d9

DOI

10.64898/2026.06.17.732811