Article

Structure of nucleosome-bound human PBAF complex

2022-05-20

Abstract excerpt

BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation. Despite structural studies of nucleosome-bound human BAF and yeast SWI/SNF family complexes, it remains elusive how PBAF-nucleosome complex is organized. Here we determined structure of 13-subunit human PBAF in complex...

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Literature Corpus work: 3db944cf-6d92-5f2a-bf63-b45b8bcf9e55
DOI: 10.1101/2022.05.20.492795

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