Article

Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids

2025-10-20

Abstract excerpt

<h4>Introduction</h4> Several studies have reported an up-regulation of interleukin (IL)-36 in the serum of patients with systemic lupus erythematosus (SLE). Here, we sought to define the mechanisms whereby IL-36 may contribute to the over-activation of type I Interferon (IFN) responses observed in SLE. <h4>Methods</h4> We carried out single-cell (sc)RNA-seq in healthy peripheral blood mononuclear cells treated...

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Literature Corpus work: 3db470ac-baa0-50d9-a306-c74211066678
DOI: 10.1101/2025.10.20.683168

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